Research Interests

Environmental and genetic influences

on formation of congenital

malformations

 Multicenter translational insights into

           Hirschsprung Disease from

              organoids to outcomes

Publications

Huo Z, Legeret C, Holland-Cunz S, Gros SJ. Treatment response evaluation in an ex vivo model of E. coli infected central venous catheter system. Front. Pediatr., 18 June 2025, Sec Pediatric Gastroenterology, Hepatology and Nutrition, Volume 13 – 2025, https://DOI.org/10.3389/fped.2025.1421992 (IF 2 (69/191))

Volkart S, Kym U, Braissant O, Delgado-Eckert E, Al-Samir S, Angresius R, Huo Z, Holland-Cunz S, Gros SJ AQP1 in the Gastrointestinal Tract of Mice: Expression Pattern and Impact of AQP1 Knockout on Colonic Function. Int J Mol Sci. 2023 Feb 10;24(4):3616. doi: 10.3390/ijms24043616.

Huo Z, Bilang R, Supuran CT, von der Weid N, Bruder E, Holland-Cunz S, Martin I, Muraro MG, Gros SJ. Perfusion-based bioreactor culture and isothermal microcalorimetry for preclinical drug testing with the carbonic anhydrase inhibitor SLC-0111 in patient-derived neuroblastoma. Int J Mol Sci 2022, 23(6), 3128; https://doi.org/10.3390/ijms23063128

Huo Z, Sa Santos M, Drenckhan A, Holland-Cunz S, Izbicki JR, Nash MA, Gros SJ. Metastatic esophageal carcinoma cells exhibit enhanced thermogenesis. Cells. 2021 May 16;10(5):1213

Pini N, Huo Z, Holland-Cunz S, Gros SJ. Increased proliferation of neuroblastoma cells under fructose metabolism can be measured by isothermal microcalorimetry. Children (Basel). 2021 Sep 7;8(9):784

Huo Z, Lomora M, Kym U, Palivan C, Holland-Cunz S, Gros SJ. AQP1 is up-regulated by hypoxia and leads to increased cell water permeability, motility and migration in neuroblastoma. Front Cell Dev Biol. 2021 Feb 11;9:605272

Huo Z, Bilang R, Brantner B, von der Weid N, Holland-Cunz SG, Gros SJ. Perspective on Similarities and Possible Overlaps of Congenital Disease Formation-Exemplified on a Case of Congenital Diaphragmatic Hernia and Neuroblastoma in a Neonate. Children 2021 Feb 22;8(2):163 (IF 2.8 (40/129))

Pini N, Huo Z, Kym U, Holland-Cunz S, Gros SJ. AQP1-driven migration is independent of other known adverse factors but requires a hypoxic undifferentiated cell profile in neuroblastoma. Children 2021 Jan 8(1): 48 (IF 2.8 (40/129))

Gros SJ, Holland-Cunz SG, Supuran CT, Braissant O. Personalized Treatment Response Assessment for Rare Childhood Tumors Using Microcalorimetry-Exemplified by Use of Carbonic Anhydrase IX and Aquaporin 1 Inhibitors. Int J Mol Sci. 2019 Oct 9;20(20). pii: E4984. doi: 10.3390/ijms20204984. (IF 5.9 (74/297))

Drenckhan A, Freytag M, Supuran CT, Sauter G, Izbicki JR, Gros SJ. CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target.. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1024-1033. doi: 10.1080/14756366.2018.1475369. (IF 4.6 (6/91))

Pini N, Pfeifle VA, Kym U, Keck S, Galati V, Holland-Cunz S, Gros SJ. Water permeability is a measure of severity in acute appendicitis. J Enzyme Inhib Med Chem. 2017 Dec;32(1) (IF 4.0 (10/61))

Ameis HM, Drenckhan A, Freytag M, Izbicki JR, Supuran CT, Reinshagen K, Gros SJ. Carbonic anhydrase IX predicts survival and is a potential therapeutic target for neuroblastoma. J Enzyme Inhib Med Chem. 2015 Apr 17:1-6 (IF 4.2 (5/60))

Ameis HM, Drenckhan A, Freytag M, Izbicki JR, Supuran CT, Reinshagen K, Holland-Cunz S, Gros SJ. Influence of hypoxia-dependent factors on the progression of neuroblastoma. Pediatr Surg Int. 2015 Oct 28 (IF 1.2 (83/121))